Socio-Gerontological Perspectives on Disease-Modifying Alzheimer’s Therapies (Lecanemab): A Delphi Study in Central Europe

Total views: 0 | Open access Open Access

Authors

https://doi.org/10.33700/jhrs.5.1.222

Keywords:

Alzheimer’s disease, Lecanemab, Delphi method, Long-term care, Health equity, Social gerontology

Abstract

Introduction: This study examines experts forecasts on societal, ethical, and structural challenges of DMT introduction in Austria, Slovenia, and Bosnia and Herzegovina—countries differing in care models and cultural attitudes toward dementia.

Aim: The aim of this study was to explore experts perspectives on the societal, ethical, and systemic implications of introducing disease-modifying Alzheimer’s therapies in Central European care contexts.

Methods: A three-round Delphi study engaged 10 multidisciplinary experts . The panel included three full professors (PhD) specialising in sociology, law and psychology, three medical doctors (MD) with specialisations in psychiatry, gerontology and geriatrics, two associate professors (PhD) in social gerontology, and one professor of public health (PhD).

Results: Strong consensus emerged on six priorities: (1) public and professional awareness/education (x̄=9.71), (2) tailored long-term care models (x̄=9.71), (3) faster drug access (x̄=9.43), (4) open dialogue to reduce stigma (x̄=8.57), (5) integrating cultural beliefs and funding (x̄=8.29), and (6) accessibility despite pricing (x̄=8.29).

Conclusion: Despite systemic disparities, experts across contexts identified shared challenges. Successful DMT integration demands culturally sensitive destigmatization, professional training, and community-based LTC adaptation.

Downloads

Download data is not yet available.

References

Aye, S., Johansson, G., Hock, C., Lannfelt, L., Sims, J. R., Blennow, K., Frederiksen, K. S., Graff, C., Molinuevo, J. L., Scheltens, P., Palmqvist, S., Schöll, M., Wimo, A., Kivipelto, M., Handels, R., Frölich, L., Zilka, N., Tolar, M., Johannsen, P., & Winblad, B. (2025). Point of view: Challenges in the implementation of new immunotherapies for Alzheimer’s disease. The Journal of Prevention of Alzheimer’s Disease, 12(1). https://doi.org/10.1016/j.tjpad.2024.100022

Clement, S., Schauman, O., Graham, T., Maggioni, F., Evans-Lacko, S., Bezborodovs, N., Morgan, C., Rüsch, N., Brown, J. S. L., & Thornicroft, G. (2015). What is the impact of mental health-related stigma on help-seeking? A systematic review of quantitative and qualitative studies. Psychological Medicine, 45(1), 11–27.

Cummings, J., Osse, A. M. L., Cammann, D., Powell, J., & Chen, J. (2024). Anti-amyloid monoclonal antibodies for the treatment of Alzheimer’s disease. BioDrugs, 38(1), 5–22. https://doi.org/10.1007/s40259-023-00633-2

Eisai Co., Ltd. (2023). Eisai’s approach to U.S. pricing for Leqembi™ (Lecanemab), a treatment for early Alzheimer’s disease. https://media-us.eisai.com/2023-01-06-EISAIS-APPROACH-TO-U-S-PRICING-FOR-LEQEMBI-TM-LECANEMAB

Hasson, F., Keeney, S., & McKenna, H. (2000). Research guidelines for the Delphi survey technique. Journal of Advanced Nursing, 32(4), 1008–1015. https://doi.org/10.1046/j.1365-2648.2000.t01-1-01567.x

Jorm, A. F. (2015). Using the Delphi expert consensus method in mental health research. Australian & New Zealand Journal of Psychiatry, 49(10), 887–897. https://doi.org/10.1177/0004867415600891

Jönsson, L., Wimo, A., Handels, R., Johansson, G., Boada, M., Engelborghs, S., Frölich, L., Jessen, F., Kehoe, P. G., Kramberger, M., Mendonça, A., Ousset, P. J., Scarmeas, N., Visser, P. J., Waldemar, G., & Winblad, B. (2023). The affordability of Lecanemab, an amyloid-targeting therapy for Alzheimer’s disease: An EADC-EC viewpoint. The Lancet Regional Health – Europe, 29, 100657.

Jünger, S., Payne, S. A., Brine, J., Radbruch, L., & Brearley, S. G. (2017). Guidance on Conducting and REporting DElphi Studies (CREDES) in palliative care: Recommendations based on a methodological systematic review. Palliative Medicine, 31(8), 684–706. https://doi.org/10.1177/0269216317690685

Karneboge, J., Haberstroh, J., Geschke, K., Perry, J., Radenbach, K., Jessen, F., & Rostamzadeh, A. (2025). Facing the new diagnostic and treatment options of Alzheimer’s disease: The necessity of informed consent. Alzheimer’s & Dementia. https://doi.org/10.1002/alz.14204

Keeney, S., Hasson, F., & McKenna, H. (2011). The Delphi technique in nursing and health research. Wiley-Blackwell. https://doi.org/10.1002/9781444392029

Kunz, L. (2025). Leqembi for Alzheimer’s disease launches in the first European Union countries. Psychiatric Times. https://www.psychiatrictimes.com/view/leqembi-for-alzheimer-disease-launches-in-first-european-union-countries

Legendre, P. (2005). Species associations: The Kendall coefficient of concordance revisited. Journal of Agricultural, Biological, and Environmental Statistics, 10(2), 226–245. https://doi.org/10.1198/108571105X46642

Maestre, G., Carrillo, M., Kaleria, R., Acosta, D., Adams, L., & Adoukonou, T. (2023). The Nairobi Declaration—Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Ageing in LMICs. Alzheimer’s & Dementia, 18(3), 1105–1108.

Okoli, C., & Pawlowski, S. D. (2004). The Delphi method as a research tool: An example, design considerations and applications. Information & Management, 42(1), 15–29. https://doi.org/10.1016/j.im.2003.11.002

Ritchie, M., Sajjadi, S. A., & Grill, J. D. (2024). Apolipoprotein E genetic testing in a new age of Alzheimer’s disease clinical practice. Neurology: Clinical Practice, 14(2), e200230. https://doi.org/10.1212/CPJ.0000000000200230

Sagehashi, Y. (2023). Leqembi to cost 2.98 million yen. PJ Jiho.

Schmidt, R. C. (1997). Managing Delphi surveys using nonparametric statistical techniques. Decision Sciences, 28(3), 763–774. https://doi.org/10.1111/j.1540-5915.1997.tb01330.x

U.S. Food and Drug Administration. (2023). Leqembi (Lecanemab-irmb) injection, for intravenous use. U.S. Food and Drug Administration. https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-alzheimers-disease-treatment

van Dyck, C. H., Swanson, C. J., Aisen, P., Bateman, R. J., Chen, C., Gee, M., Kanekiyo, M., Li, D., Reyderman, L., Cohen, S., Froelich, L., Katayama, S., Sabbagh, M., Vellas, B., Watson, D., Dhadda, S., Irizarry, M., Kramer, L. D., & Iwatsubo, T. (2023). Lecanemab in early Alzheimer’s disease. New England Journal of Medicine, 388(1), 9–21.

Walsh, S., Merrick, R., Milne, R., Nurock, S., Richard, E., & Brayne, C. (2024). Considering challenges for the new Alzheimer’s drugs: Clinical, population, and health system perspectives. Alzheimer’s & Dementia. https://doi.org/10.1002/alz.14108

Xia, X., Aye, S., Frisell, O., Aho, E., Handels, R., Li, Y., & Jönsson, L. (2025). The cost-effective price of Lecanemab for patients with early Alzheimer’s disease in Sweden. PharmacoEconomics, 43(10), 1251–1266.

Yeo-Teh, N. S. L., & Tang, B. L. (2023). A review of scientific ethics issues associated with the recently approved drugs for Alzheimer’s disease. Science and Engineering Ethics, 29(1). https://doi.org/10.1007/s11948-022-00422-0

Zimmermann, M. (2017). Alzheimer’s disease metaphors as a mirror and a lens to the stigma of dementia. Literature and Medicine, 35(1), 71–97.

Published

18.05.2026

How to Cite

Standeker, N., Salkunič, Šefik, Goriup, J., Jejčič, K., & Berčan, M. (2026). Socio-Gerontological Perspectives on Disease-Modifying Alzheimer’s Therapies (Lecanemab): A Delphi Study in Central Europe. Journal of Health and Rehabilitation Sciences, 5(1), 1–19. https://doi.org/10.33700/jhrs.5.1.222

Issue

Section

Social Policy

Citations

Metrics