Micronutrient Supplementation in Children with Autism Spectrum Disorder: An Open-Label Trial

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Micronutrients, autism spectrum disorder (ASD), nutrition, supplements, clinical trial


Aim: To investigate the change in core and associated behaviours of autism spectrum disorder (ASD) following micronutrient supplementation.

Methods: Adolescents and adults with ASD (N=16, aged 11-22) participated in an 8-week open label study of micronutrients supplements. Measures of behaviour and social responsiveness, using Autism Behaviour Inventory – Short (ABI-S) and Social Responsiveness Scale (SRS) respectively, were completed by parents and teachers at baseline and end of the study. Paired t-tests were used to compare the pre- and post-treatment mean scores.

Results: Eleven participants completed the study. Mean scores on both clinical outcomes showed improvements (decreases) over the study period, but none were statistically significant. Parent-reported ABI-S scores decreased (improved) by 11.5% (effect size=-0.52, p=0.08), teacher-reported ABI-S scores improved by 3.7% (effect size=-0.16, p=0.31), and parent-reported SRS scores improved by 8.6% (effect size=-0.56, p=0.05). There were no adverse events reported.

Conclusion: This study adds to the mixed findings of micronutrient supplementation in individuals with ASD, consistent with previous studies. Micronutrients were safely tolerated. In the future, randomized controlled trials with a larger sample size are needed to provide more insight on the potential benefits of micronutrients in ASD.


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14.09.2023 — Ahead of print updated on 03.10.2023 as final version


How to Cite

Hossain, B., Benes, J., Bent, S., Widjaja, F., Parenteau, C., & Hendren, R. (2023). Micronutrient Supplementation in Children with Autism Spectrum Disorder: An Open-Label Trial. Journal of Health and Rehabilitation Sciences, 2(2), 30–39. https://doi.org/10.33700/jhrs.2.2.87 (Original work published September 14, 2023)



Autism Research