Micronutrient Supplementation in Children with Autism Spectrum Disorder: An Open-Label Trial
Open AccessAuthors
-
Bushra Hossain
University of California, San Francisco, USA
https://orcid.org/0000-0001-5492-6499
- Jazzy Benes University of California, San Francisco, USA
-
Stephen Bent
University of California, San Francisco, USA
https://orcid.org/0000-0002-4767-9714
- Felicia Widjaja University of California, San Francisco, USA
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China Parenteau
University of California, San Francisco, USA
https://orcid.org/0000-0001-6812-9263
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Robert Hendren
University of California, San Francisco, USA
https://orcid.org/0000-0001-8470-4862
Keywords:
Micronutrients, autism spectrum disorder (ASD), nutrition, supplements, clinical trialAbstract
Aim: To investigate the change in core and associated behaviours of autism spectrum disorder (ASD) following micronutrient supplementation.
Methods: Adolescents and adults with ASD (N=16, aged 11-22) participated in an 8-week open label study of micronutrients supplements. Measures of behaviour and social responsiveness, using Autism Behaviour Inventory – Short (ABI-S) and Social Responsiveness Scale (SRS) respectively, were completed by parents and teachers at baseline and end of the study. Paired t-tests were used to compare the pre- and post-treatment mean scores.
Results: Eleven participants completed the study. Mean scores on both clinical outcomes showed improvements (decreases) over the study period, but none were statistically significant. Parent-reported ABI-S scores decreased (improved) by 11.5% (effect size=-0.52, p=0.08), teacher-reported ABI-S scores improved by 3.7% (effect size=-0.16, p=0.31), and parent-reported SRS scores improved by 8.6% (effect size=-0.56, p=0.05). There were no adverse events reported.
Conclusion: This study adds to the mixed findings of micronutrient supplementation in individuals with ASD, consistent with previous studies. Micronutrients were safely tolerated. In the future, randomized controlled trials with a larger sample size are needed to provide more insight on the potential benefits of micronutrients in ASD.
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Adams, J. B., Audhya, T., Geis, E., Gehn, E., Fimbres, V., Pollard, E. L., Mitchell, J., Ingram, J., Hellmers, R., Laake, D., Matthews, J. S., Li, K., Naviaux, J. C., Naviaux, R. K., Adams, R. L., Coleman, D. M., & Quig, D. W. (2018). Com-prehensive Nutritional and Dietary Interven-tion for Autism Spectrum Disorder-A Random-ized, Controlled 12-Month Trial. Nutrients, 10(3), 369.
Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., Gehn, E., Loresto, M., Mitchell, J., Atwood, S., Barn-house, S., & Lee, W. (2011). Nutritional and metabolic status of children with autism vs. Neurotypical children, and the association with autism severity. Nutrition & Metabolism, 8(1), 34.
Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., Gehn, E., Loresto, M., Mitchell, J., Atwood, S., Barn-house, S., & Lee, W. (2011). Effect of a vita-min/mineral supplement on children and adults with autism. BMC Pediatrics, 11, 111.
Adams, J. B., Kirby, J., Audhya, T., Whiteley, P., & Bain, J. (2022). Vitamin/mineral/micronutrient supplement for autism spectrum disorders: A research survey. BMC Pediatrics, 22(1), 590.
Alzghoul, L., AL-Eitan, L., Aladawi, M., Odeh, M., & Hantash, O. (2020). The Association Be-tween Serum Vitamin D3 Levels and Autism Among Jordanian Boys. Journal of Autism and Developmental Disorders, 1-6.
American Psychiatric Association. (2013). Autism Sprectrum Disorder. In Diagnostic and statisti-cal manual of mental disorders (5th ed.).
Bent, S., Lawton, B., Warren, T., Widjaja, F., Dang, K., Fahey, J. W., Cornblatt, B., Kinchen, J. M., Delucchi, K., & Hendren, R. L. (2018). Identifi-cation of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Molecular Autism, 9, 35.
Bent, S., McDonald, M., & Hendren, R. (2022). The Oak Hill Method: Connecting to Students with Autism. BookBaby.
Cheng, B., Zhu, J., Yang, T., Guo, M., Lai, X., Li, Q., Chen, J., & Li, T. (2020). Vitamin A deficiency increases the risk of gastrointestinal comorbidi-ty and exacerbates core symptoms in children with autism spectrum disorder. Pediatric Re-search, 89, 211-216.
Chistol, L. T., Bandini, L. G., Must, A., Phillips, S., Cermak, S. A., & Curtin, C. (2018). Sensory Sensitivity and Food Selectivity in Children with Autism Spectrum Disorder. Journal of Au-tism and Developmental Disorders, 48(2), 583–591.
Dietz, P. M., Rose, C. E., McArthur, D., & Maenner, M. (2020). National and State Estimates of
Adults with Autism Spectrum Disorder. Journal of autism and developmental disorders, 50(12), 4258–4266.
Duku, E., Vaillancourt, T., Szatmari, P., Georgiades, S., Zwaigenbaum, L., Smith, I. M., Bryson, S., Fombonne, E., Mirenda, P., Roberts, W., Volden, J., Waddell, C., Thompson, A., Bennett, T., & Pathways in ASD Study Team. (2013). In-vestigating the measurement properties of the social responsiveness scale in preschool chil-dren with autism spectrum disorders. Journal of Autism and Developmental Disorders, 43(4), 860–868.
Fraguas, D., Díaz-Caneja, C. M., Pina-Camacho, L., Moreno, C., Durán-Cutilla, M., Ayora, M., González-Vioque, E., de Matteis, M., Hendren, R. L., Arango, C., & Parellada, M. (2019). Die-tary Interventions for Autism Spectrum Disor-der: A Meta-analysis. Pediatrics, 144(5), e20183218.
Gustafsson, H. C., Sullivan, E. L., Nousen, E. K., Sullivan, C. A., Huang, E., Rincon, M., ... & Loftis, J. M. (2018). Maternal prenatal depres-sion predicts infant negative affect via mater-nal inflammatory cytokine levels. Brain, be-havior, and immunity, 73, 470-481.
Indika, N.-L. R., Frye, R. E., Rossignol, D. A., Owens, S. C., Senarathne, U. D., Grabrucker, A. M., Perera, R., Engelen, M. P. K. J., & Deutz, N. E. P. (2023). The Rationale for Vitamin, Mineral, and Cofactor Treatment in the Precision Medi-cal Care of Autism Spectrum Disorder. Journal of Personalized Medicine, 13(2), 252.
Johnstone, J. M., Hatsu, I., Tost, G., Srikanth, P., Eiterman, L. P., Bruton, A. M., Ast, H. K., Robi-nette, L. M., Stern, M. M., Millington, E. G., Gracious, B. L., Hughes, A. J., Leung, B. M. Y., & Arnold, L. E. (2022). Micronutrients for At-tention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial. Journal of the American Acade-my of Child and Adolescent Psychiatry, 61(5), 647–661.
Karhu, E., Zukerman, R., Eshraghi, R. S., Mittal, J., Deth, R. C., Castejon, A. M., Trivedi, M., Mit-tal, R., & Eshraghi, A. A. (2020). Nutritional in-terventions for autism spectrum disorder. Nutri-tion reviews, 78(7), 515–531.
Kittana, M., Ahmadani, A., Stojanovska, L., & Att-lee, A. (2021). The Role of Vitamin D Supple-mentation in Children with Autism Spectrum Disorder: A Narrative Review. Nutrients, 14.
Li, Y.-J., Li, Y.-M., & Xiang, D.-X. (2018). Supple-ment intervention associated with nutritional deficiencies in autism spectrum disorders: A systematic review. European Journal of Nutri-tion, 57(7), 2571–2582.
Maenner, M. J., Warren, Z., Williams, A. R., Amoakohene, E., Bakian, A. V., Bilder, D. A., Durkin, M. S., Fitzgerald, R. T., Furnier, S. M., Hughes, M. M., Ladd-Acosta, C. M., McArthur, D., Pas, E. T., Salinas, A., Vehorn, A., Williams, S., Esler, A., Grzybowski, A., Hall-Lande, J., Nguyen, R. H. N., … Shaw, K. A. (2023). Prevalence and Characteristics of Au-tism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabili-ties Monitoring Network, 11 Sites, United States, 2020. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. :2002), 72(2), 1–14.
Monteiro, M., Santos, A., Gomes, L., & Rito, R. (2020). Autism Spectrum Disorder: A systemat-ic review about nutritional interventions. Re-vista Paulista de Pediatria, 38.
McElhanon, B. O., McCracken, C., Karpen, S., & Sharp, W. G. (2014). Gastrointestinal symptoms in autism spectrum disorder: A meta-analysis. Pediatrics, 133(5), 872–883.
Pandina, G., Ness, S., Trudeau, J., Stringer, S., Knoble, N., Lenderking, W. R., & Bangerter, A. (2021). Qualitative evaluation of the Autism Behavior Inventory: Use of cognitive inter-viewing to establish validity of a caregiver re-port scale for autism spectrum disorder. Health and Quality of Life Outcomes, 19(1), 26.
Poudineh, M., Parvin, S., Omidali, M., Nikzad, F., Mohammadyari, F., Sadeghi Poor Ranjbar, F., Rasouli, F., Nanbakhsh, S., & Olangian-Tehrani, S. (2023). The Effects of Vitamin Therapy on ASD and ADHD: A Narrative Re-view. CNS & Neurological Disorders Drug Tar-gets, 22(5), 711–735.
Sathe, N., Andrews, J. C., McPheeters, M. L., & War-ren, Z. E. (2017). Nutritional and Dietary Inter-ventions for Autism Spectrum Disorder: A Sys-tematic Review. Pediatrics, 139(6), e20170346.
J. (2019). Human gut microbiome changes during a 10-week Randomised Control Trial for micro-nutrient supplementation in children with at-tention deficit hyperactivity disorder. Scien-tific reports, 9(1), 10128.
Stevens, A. J., Rucklidge, J. J., Darling, K. A., Eg-gleston, M. J., Pearson, J. F., & Kennedy, M.
A. (2018). Methylomic changes in response to mi-cronutrient supplementation and MTHFR genotype. Epigenomics, 10(09), 1201-1214.
Shaw, K. A., Bilder, D. A., McArthur, D., Williams, A. R., Amoakohene, E., Bakian, A. V., Durkin, M. S., Fitzgerald, R. T., Furnier, S. M., Hughes, M. M., Pas, E. T., Salinas, A., Warren, Z., Wil-liams, S., Esler, A., Grzybowski, A., Ladd-Acosta, C. M., Patrick, M., Zahorodny, W., Green, K. K., … Maenner, M. J. (2023). Early Identification of Autism Spectrum Disorder Among Children Aged 4 Years - Autism and Developmental Disabilities Monitoring Net-work, 11 Sites, United States, 2020. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. 2002), 72(1), 1–15.
Song, L., Luo, X., Jiang, Q., Chen, Z., Zhou, L., Wang, D., & Chen, A. (2020). Vitamin D Sup-plementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis. Clinical Psychopharmacology and Neurosci-ence, 18, 203 - 2123.
Wang, Z., Ding, R., & Wang, J. (2020). The Associa-tion between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Re-view and Meta-Analysis. Nutrients, 13.
Zhu, J., Guo, M., Yang, T., Lai, X., Tang, T., Chen, J., Li, L., & Li, T. (2020). Nutritional Status and Symptoms in Preschool Children with Autism Spectrum Disorder: A Two-Center Comparative Study in Chongqing and Hainan Province, China. Frontiers in pediatrics, 8, 469.
Stevens, A. J., Purcell, R. V., Darling, K. A., Eg-gleston, M. J., Kennedy, M. A., & Rucklidge, J.
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Copyright (c) 2023 Bushra Hossain, Jazzy Benes, Stephen Bent, Felicia Widjaja, China Parenteau, Robert Hendren
This work is licensed under a Creative Commons Attribution 4.0 International License.
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